Updated Covid-19 Boosters are Expected in Augest. Will it be too late?

now the uk vaccination authorities have just approved the covet vaccine from moderna with the bivalent the bivalent vaccine so it's got two components to it one part is the original. strain the original 2020 strain, but the other component of the vaccine is designed to be active against ba1 omicron. which of course we don't have any more and the country has decided to take on this vaccination campaign for the the autumn the fall of 2022 as far as i can see based on a sample size of 437. 

I Would Have Thought Is Fairly Small But

it's more nuanced than that so if you want to know the details then then we'll we'll take a look at that now this initial data comes from this what we don't like on this channel science by press release so this has just come from moderna here: and the details are there but they are fairly scant so let's dive into those straight away bivalent covered boosters

vaccine and this is what they're. calling it here the the one two seven three which was the original one dot two one four as we said the original was the mrna one two three vaccine.

So, that that's what they're doing so now they're claiming superior natural neutralizing antibody response baseline seronegative participants this confused me a little bit because. i'm not sure where they would get zero negative participants from because the data from the office for national statistics shows that the zero positivity in the uk for example is about 97 and has been over 99 in in. some groups in some times. so um interesting but they seem to use. zero negative these were people that would presumably have been naive to the virus

but quite where they got those from would be interesting when we read the final paper.  they said there's increased neutralizing genomic mean teeters that that's the amount of antibody basically in the eightfold above baseline level. it looks like they took people without any antibodies here and then found the antibodies were increased eight times above the levels of antibodies that they had which is

Baseline Level

if you're now confused so am i because they took zero negative people this seems to be saying and then they found an eightfold increase in antibodies against the baseline level of antibodies but that's that that's a direct quote from there from their site so i'm sure this will all be clarified when we get the final peer-reviewed paper on this study at least we would hope so they're giving a 50 microgram booster dose they found it was well tolerated in 437 so that's 437 people have done this study on well tolerated in 437 people you might think that's not a big enough sample size to get good safety data on and i would agree but that's what they've done.  

Which This Vaccine Was Designed

so whether they didn't have space for but i didn't i didn't see that there but this is against the ba1 as well as the original one.

How Much Ba1 Do We Have At The Moment

well the technical date de briefing for the uk is way out of date it's technical briefing 44 i think it's from the set 22nd of out of date but this was the figures from then saskaroon of virus 2 variant  of concern about under investigation in england ba2 3.4 ba four seven point seventeen point two percent 78 and others naught point seven so the only one that the ba1 could possibly

Final Words

we looked at this few days ago so i'm not going to go over again but cardiovascular events were found in 29.24 of the 13 to 18 year olds involved most common effects were tachycardia shortness of breath palpitations chest pain had at least one biomarker whether it was troponins or whether it was creatine creating kinase being a  a biomarker for myocyte damage as indeed is troponin will we need numbers much greater than 437 to completely clarify that  the answer to that question that's what's happening um so um we're now a bit more up to date and time.